1. Any substance other than those required for the maintenance of normal health, which, when taken into the living organism, may modify one or more of its functions. (WHO)
2. Medicine : any substance with the potential to prevent or cure disease or enhance physical or mental welfare.
3. Pharmacology : an agent that alters the biochemical or physiological processes of tissues or organisms.
4. Socially unacceptability
5. Illegality
6. Harmfulness
7. Being used without medical approval
8. Being used excessively
9. Illegal use
10. Unsanctioned use
11. Hazardous use
12. Dysfunctional use
13. Non-medical drug use
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